RESEARCH: INVESTIGATING THE GENETIC CAUSES OF BOWEL CANCER
The aim of this collaborative project between EPCC and Colon Cancer Genetic Group (CCGG) of the MRC Human Genetics Unit at the Western General Hospital was to investigate genetic causes of bowel cancer.
Understanding the relationship between genetic markers and colorectal cancer was thought to be a first step in identifying individuals at risk of the disease and to allow appropriate preventive measures to be taken. The studied dataset consisted of 565,000 genetic markers with real data from 1000 cancer cases and 1000 matched controls.
On the Blue Gene system, the project was aimed at investigating the effect of each individual genetic marker, which required around 565,000 computations.
During this phase EPCC successfully ported, parallelised and optimised the FORTRAN serial code on the BlueGene/L computer. The predicted serial run time for this O(N) problem was 10,800 days on a single CPU. The parallel code when run on 128 processors on BlueGene/L took 6.5 hours! The results led to a publication in the Nature Genetics.